Reduction of Renal Ischemia-Reperfusion-Induced Liver Side Effects in Rats through Antioxidative Properties of Narigenin

  • Roshankhah, Shiva
  • Abdolmaleki, Amir
  • Salahshoor, Mohammad Reza
Publication date
November 2020

Abstract

Background & Objective: Pathophysiology of Ischemia/Reperfusion (Isc/R) can cause renal and hepatic damages. Naringenin (NAR) is a flavonoid with potent antioxidant properties. In the present study, the effects of NAR on the liver after the renal Isc/R procedure were investigated. Materials & Methods: Sixty-four Wistar rats were divided into eight groups. The animals in the control group received dimethyl sulfoxide (DMSO). Group 2 as the Isc/R group went under the Isc/R procedure. Groups 3, 4, and 5 as the NAR groups received 20, 50, and 100 mg/kg of NAR, respectively. Groups 6, 7, and 8 were the Isc/R+NAR groups. The NAR was administrated for four consecutive weeks orally. Levels of the expression of p53, Bcl2, and Bax genes were assess...

Extracted data

We use cookies to provide a better user experience.