Effect of Magnesium Sulphate on Intra Operative Anesthetic Requirements and Post Operative Analgesia in Plastic Surgery Patients

Background: The management of postoperative pain is one of the most challenging issue for anesthesiologists. The anaesthetic and analgesic-sparing effect of Magnesium sulphate may enable anaesthesiologists to reduce the use of anaesthetics during surgery and the use of analgesics after surgery. To evaluate the effect of preoperative systemic magnesium sulphate on intra-operative vecuronium isoflurane and fentanyl consumption and post-operative analgesia. Methods: 60 ASA I-II patients of both sex, group M received magnesium sulphate and group S Saline as per study protocol. Patients characteristics, heart rate, systolic, diastolic and mean blood pressure, mean alveolar concentration were noted at definite time intervals. Pain score, dosage and timing of rescue analgesia, episodes of shivering, vomiting or any other significant side effect were recorded till 8th hr. Statistical analysis was performed and P-value below 0.05 was considered significant. Results: VAS score at 1hr and 4hr, which were significantly lower in Group M and need for rescue analgesia was less ingroup M as compared to group S. None of the patients in group M had shivering and vomiting as compare to group S. Our study demonstrate significant reduction in the consumption of isoflurane and vecuronium magnesium group. Magnesium sulphate was also found having more advantages during the postoperative periods associated with better recovery profiles. Conclusion: Magnesium has anaesthetic, analgesic and muscle relaxant properties and its intraoperative use lead to significantlyreduces the drug requirements of vecuronium and isoflurane during anaesthesia and post-operative consumption of ketorolac and reduced VAS score