Data from: Imaging markers of small vessel disease and 'brain frailty' and outcomes in acute stroke

Appleton, Jason Philip
Woodhouse, Lisa J.
Adami, Alessandro
Becker, Jennifer L.
Berge, Eivind
Cala, Lesley Ann
Casado, Ana M.
Caso, Valeria
Christensen, Hanne K.
Dineen, Robert A.
Gommans, John
Koumellis, Panayiotis
Szatmari, Szabolcs
Sprigg, Nikola
Bath, Philip M.
Wardlaw, Joanna M.

Publication date

August 2020

DOI

Abstract

Objective: We assessed the association of baseline imaging markers of cerebral small vessel disease (SVD) and 'brain frailty' with clinical outcome after acute stroke in the Efficacy of Nitric Oxide in Stroke (ENOS) trial. Methods: ENOS randomised 4011 patients with acute stroke (<48 hours of onset) to transdermal glyceryl trinitrate (GTN) or no GTN for 7 days. The primary outcome was functional outcome (modified Rankin Scale, mRS) at day 90. Cognition was assessed via telephone at day 90. Stroke syndrome was classified using the Oxfordshire Community Stroke Project classification. Brain imaging was adjudicated masked to clinical information and treatment, and assessed SVD (leukoaraiosis, old lacunar infarcts/lacunes, atrophy) and 'brain fr...