New directions in treatment of the ischemic stroke

Zaremba Bartłomiej, Gorecka Adrianna, Wysokińska Olga, Cholewa Krystian, Milanowska Joanna. New directions in treatment of the ischemic stroke. Journal of Education, Health and Sport. 2020;10(7):66-77. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.07.006 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.07.006 https://zenodo.org/record/3937855 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.06.2020. Revised: 26.06.2020. Accepted: 10.07.2020. New directions in treatment of the ischemic stroke (1)Bartłomiej Zaremba, (1)Adrianna Gorecka, (1)Olga Wysokińska, (1)Krystian Cholewa, (2)Joanna Milanowska (1) Studenckie Koło Naukowe przy Zakładzie Psychologii Stosowanej, Uniwersytet Medyczny w Lublinie (2) Zakład Psychologii Stosowanej, Uniwersytet Medyczny w Lublinie, Aleje Racławickie 1, 20-059 Lublin, Poland zaremba.bartek28@gmail.com Abstract Stroke remains a leading cause of death and disability worldwide. The cause is decrease or total blocking of blood perfusion in brain and fast recognition is essential to conduct proper treatment. Currently commonly used methods are thrombolysis and mechanical thrombectomy, which high efficacy is observed only if they are performed within a few hours of the first symptoms. Hence loads of people, who are diagnosed later, become unable to undergo effective treatment. In the study are presented pathogenesis, epidemiology, classification, diagnosis and current treatment of the disease, but the main aim of the study is to present the results of the reports on new treatments for ischemic stroke. The research method is a review of the available literature published in PubMed, UpToDate and Google scholar databases. In the study were reviewed new methods, which can be alternative for currently used ones. They are small molecules including fluoxetine, aripiprazole, L-DOPA, cholinergic and noradrenergic drugs, growth factors (HCG, EPO), monoclonal antibodies, allogenic stem cells, neurostimulators, robotic therapy and telerehabilitation. They give hope for curing a larger number of patients and improving effects of rehabilitation after ischemic stroke. However most of the methods, which are presented in this study require the use of tests that will allow checking their safety and application. Key words: ischemic stroke; thrombolysis; thrombectomy; growth factors; brain stimulatio