Determination of biochemical indicators when modeling HIPEC with cisplatin on rats

Pykhtieieva E. D., Tretyakov A. M., Gozhenko A. I., Pykhtieieva E. G. Determination of biochemical indicators when modeling HIPEC with cisplatin on rats. Journal of Education, Health and Sport. 2019;9(3):626-631. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3309034 http://ojs.ukw.edu.pl/index.php/johs/article/view/7143 https://pbn.nauka.gov.pl/sedno-webapp/works/917930 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 20.02.2019. Revised: 28.02.2019. Accepted: 29.03.2019. DETERMINATION OF BIOCHEMICAL INDICATORS WHEN MODELING HIPEC WITH CISPLATIN ON RATS E. D. Pykhtieieva, A. M. Tretyakov, A. I. Gozhenko, E. G. Pykhtieieva Ukrainian Research Institute of Transport Medicine, Odessa, Ukraine Abstract HIPEC (Hyperthermic intraperitoneal chemotherapy; hyperthermic intraoperative intraperitoneally chemoperfusion) is a method of treating primary and secondary peritoneal tumors. Perfusion of the peritoneal cavity with solutions with cytotoxic agents at a temperature above the physiological norm (41-43 ° C) occurs when HIPEC. The conducted biochemical studies suggest that with HIPEC, elevated temperature is an important factor and leads to potentiation of the toxic effect of cisplatin. Despite the higher accumulation of platinum in the kidneys during cold solution perfusion, the resulting change in biochemical parameters is higher with the simultaneous action of elevated temperature and cisplatin. Key words: rats, cisplatin, temperature, acid phosphatase, lipid peroxidation, creatinine