Impact of surfactant on renal function of adult Wistar rats

Popova T. M. Impact of surfactant on renal function of adult Wistar rats. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2018;1(51):91-97. ISSN 1818-9385 DOI http://dx.doi.org/10.5281/zenodo.1230274 http://aptm.org.ua УДК 612.46: 615.099] 616-074-092.9 DOI http://dx.doi.org/10.5281/zenodo.1238652 IMPACT OF SURFACTANT ON RENAL FUNCTION OF ADULT WISTAR RATS Popova T.M. Kharkov Medical Academy of Postgraduate Education, Kharkov, Ukraine e-mail: popovatatyanamikh@gmail.com The study is focused on elucidate the effect of Laprol-604 on rat renal function. The model of intoxication was produced by oral administration of water solution Laprol-604 to rats of experimental groups. The Laprol-604 administration induced electrolyte imbalance in blood serum and urine of rats. The obtained results testify the renal excretion of nitrogen metabolism products was decreased by the influence of Laprol-604. The adverse effect of Laprol-604 depended on its dose. Keywords: kidney, Laprol-604, surfactant, polyols, glomerular filtration rate, creatinine, urea, sodium, potassium, chloride. The present study is a fragment of the scientific research work of the KhMAPE "Pathochemical mechanisms of radiotoxins impact on the body and the principles of their early diagnosis and correction" (state registration number № 0117U000589)