FORMULATION AND EVALUATION OF 5 FU LOADED EUDRAGIT MICROSPHERE FOR EFFECTIVE MANAGEMENT OF COLON CANCER

-Fluorouracil (5-FU) has a wide anticancer activity versus several types of solid tumors. The activity of 5-FU can be improved and its toxicity can be diminished by enhancing the relative specific accumulation in the tumor regions. The aim of this work was to develop Eudragit RS100 based 5-FU microsponges (MS) for treatment of colon cancer. Oil in oil emulsion solvent diffusion method was used for the preparation of 5-FU sustained release Eudragit RS100 MS. MS were characterized for their encapsulation efficiency, production yield, and drug release profiles. the mean particle size for Eudragit RS 100 was found in the range of 41.9±3.387 µm to 43.8±4.405 µm. As shown in the table the entrapment was less for Eudragit RS 100 and found in the range of 28.82 to 39.82 %. Methanol was used to dissolve the drug in all formulation and was an important factor that affects the production yield. The F3 was showed sustained release of drug up to 12 hours as compared to other formulations F1 and F2. The results demonstrated that 5-FU with Eudragit RS100 was successfully formulated as sustained release manner and could be a substitution delivery method of 5-FU for oral anticancer treatment