Some novel 2-methyl-3-(1'3' 4' -thiadiazoyl)-4-(3H)quinazolinones with anticonvulsant and CNS depressant activity

Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar-470 003, Madhya Pradesh, India E-mail : pmishra51 @rediffmail.com Fax : 91-07582-264236 Manuscript received 4 January 2006, revised 19 June 2006, accepted 23 August 2006 A series comprising six novel 2-methyl-3-(1'3'4'-thiadiazoyi)-4(3H)quinazolinones have been synthesized by conden sing different 2-amino-1,3,4-thiadiazoles with 2-methyl benzoxazin-2-one and evaluated for anticonvulsant and CNS depressant activity. Compound Sf exhibited both anticonvulsant and CNS depressant activity