Benchmarking single-cell RNA-seq (scRNA-seq) and single-cell ATAC-seq (scATAC-seq) computational tools demands simulators to generate realistic sequencing reads. However, none of the few read simulators aim to mimic real data. To fill this gap, we introduce scReadSim, a single-cell RNA-seq and ATAC-seq read simulator that allows user-specified ground truths and generates synthetic sequencing reads (in FASTQ and BAM formats) by mimicking real data. At both read-sequence and read-count levels, scReadSim mimics real scRNA-seq and scATAC-seq data. Moreover, scReadSim provides ground truths, including unique molecular identifier counts for scRNA-seq and open chromatin regions for scATAC-seq. In particular, scReadSim allows users to design cell-t...
Abstract Single-cell RNA-seq technologies require library preparation prior to sequencing. Here, we ...
Abstract RNA sequencing (RNA-seq) is a genomic approach for the detection and quantitative analysis ...
The recent rapid spread of single cell RNA sequencing (scRNA-seq) methods has created a large variet...
Techniques for single-cell RNA sequencing (scRNA-seq) has enabled unprecedented insights into gene e...
Motivation Single-cell RNA-sequencing (scRNA-seq) has revolutionized biological sciences by revealin...
© 2020 Luyi TianThe fast development of single cell RNA sequencing (scRNAseq) presents new challenge...
Single-cell RNA sequencing (scRNA-seq) offers new possibilities to address biological and medical qu...
BACKGROUND: With the emergence of hundreds of single-cell RNA-sequencing (scRNA-seq) datasets, the n...
Abstract Single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq...
Abstract Motivation Single cell RNA-seq (scRNA-s...
Motivation: Single-cell RNA sequencing (scRNA-seq) is increasingly used to study gene expression at ...
Single-cell RNA sequencing (scRNA-seq) offers great new opportunities for increasing our understandi...
Thanks to innovative sample-preparation and sequencing technologies, gene expression in individual c...
This repository contains the real and synthetic datasets used in the paper "Benchmarking the Autoenc...
Single-cell RNA-seq technologies require library preparation prior to sequencing. Here, we present t...
Abstract Single-cell RNA-seq technologies require library preparation prior to sequencing. Here, we ...
Abstract RNA sequencing (RNA-seq) is a genomic approach for the detection and quantitative analysis ...
The recent rapid spread of single cell RNA sequencing (scRNA-seq) methods has created a large variet...
Techniques for single-cell RNA sequencing (scRNA-seq) has enabled unprecedented insights into gene e...
Motivation Single-cell RNA-sequencing (scRNA-seq) has revolutionized biological sciences by revealin...
© 2020 Luyi TianThe fast development of single cell RNA sequencing (scRNAseq) presents new challenge...
Single-cell RNA sequencing (scRNA-seq) offers new possibilities to address biological and medical qu...
BACKGROUND: With the emergence of hundreds of single-cell RNA-sequencing (scRNA-seq) datasets, the n...
Abstract Single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq...
Abstract Motivation Single cell RNA-seq (scRNA-s...
Motivation: Single-cell RNA sequencing (scRNA-seq) is increasingly used to study gene expression at ...
Single-cell RNA sequencing (scRNA-seq) offers great new opportunities for increasing our understandi...
Thanks to innovative sample-preparation and sequencing technologies, gene expression in individual c...
This repository contains the real and synthetic datasets used in the paper "Benchmarking the Autoenc...
Single-cell RNA-seq technologies require library preparation prior to sequencing. Here, we present t...
Abstract Single-cell RNA-seq technologies require library preparation prior to sequencing. Here, we ...
Abstract RNA sequencing (RNA-seq) is a genomic approach for the detection and quantitative analysis ...
The recent rapid spread of single cell RNA sequencing (scRNA-seq) methods has created a large variet...