AMELIORATIVE EFFECTS OF THE AQU0EOUS ROOT EXTRACTS OF CURCUMA LONGA (TURMERIC) ON LEAD ACETATE-INDUCED PREFRONTAL CORTEX TOXICITY IN ADULT FEMALE WISTAR RATS

Abstract: Background: The prefrontal cortex is an area of the brain in the frontal lobe of both cerebral hemispheres that is responsible for decision making, behavior and emotional control (Miller and Cohen, 2001). Exposure to Lead has been linked to neurotoxicity leading to diverse neurological disorders. There are increasing literatures showing medicinal use of Curcuma longa (turmeric), especially in neurological disorders. Aim: This study aims at exploring the ameliorative potency of the aqueous root extract of Curcuma longa (ARECL) on the histology of the prefrontal cortex following lead-acetate induced neurotoxicity. Methodology: Thirty (30) non-pregnant adult female wistar rats (150-200g) were divided into 6 groups of 5 rats each. Group A received only normal saline. Group B received 30mg/kg of lead acetate daily. Each of Groups C-E was all exposed to simultaneous administration of 30mg/kg of lead acetate and 100mg/kg, 300mg/kg and 500mg/kg of ARECL respectively daily. Group F received simultaneous administration of 30mg/kg of lead acetate and 100mg/kg of Vitamin E daily. All administrations were oral and the experiment lasted 24 days. The animals were sacrificed 24 hours after their last treatment via ketamin (100mg/ml) as anaesthesia. The brain was carefully harvested, washed in normal saline and fixed for 24 hours after which the prefrontal cortex was further harvested, fixed accordingly and processed for routine H&E staining. Results: Group B administered with only 30mg/kg of lead-acetate displayed pathologies such as vacuolated cytoplasm, widespread tissue edema and loss of neurons. Similar characteristics were noticed in animal groups C-D. Animal groups E-F displayed the normal histoarchitecture of the prefrontal cortex with no pathologies. Conclusion: The Aqueous root extract of Curcuma longa has ameliorative potency in the management of lead-induced neurotoxicity. Keywords: Curcuma longa, lead acetate-induced toxicity, prefrontal cortex, wistar rats. Title: AMELIORATIVE EFFECTS OF THE AQU0EOUS ROOT EXTRACTS OF CURCUMA LONGA (TURMERIC) ON LEAD ACETATE-INDUCED PREFRONTAL CORTEX TOXICITY IN ADULT FEMALE WISTAR RATS Author: Christian Chiemeka Ozor, Blessing Ngozi Anih International Journal of Novel Research in Life Sciences ISSN 2394-966X Vol. 10, Issue 3, May 2023 - June 2023 Page No: 8-14 Novelty Journals Website: www.noveltyjournals.com Published Date: 12-May-2023 DOI: https://doi.org/10.5281/zenodo.7928731 Paper Download Link (Source) https://www.noveltyjournals.com/upload/paper/AMELIORATIVE%20EFFECTS-12052023-5.pdfInternational Journal of Novel Research in Life Sciences, ISSN 2394-966X, Novelty Journals, Website: www.noveltyjournals.co