Comparison of inflammatory markers in euthyroid patients with positive and negative thyroid autoantibodies

Objective: Autoimmune thyroid diseases can cause certain levels of systemic inflammation in the body. In this research, it was aimed to evaluate the thyroid autoantibody levels and systemic inflammation markers of those applicants for our outpatient clinic who were found to be euthyroid. Methods: In our study, 220 patients, aged between 18-75 years, who were found to be euthyroid after thyroid hormone evaluation and did not use any thyroid medication, were retrospectively included. Patients' age, height, weight, hemogram parameters, sedimentation, C-reactive protein (CRP), freeT3 (fT3), freeT4 (fT4), thyroid stimulating hormone (TSH), anti-thyroglobulin (anti-TG), and anti-thyroid peroxidase (anti-TPO) values were recorded retrospectively by the researchers by examining the patient files. The relationship between inflammatory parameters, thyroid autoantibody levels (anti-TG and anti-TPO), monocyte–to-lymphocyte ratio (MLR), platelet –to- lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) were subjected to our investigation. Results: The individuals who were participated in the research had a mean age of 46.2±13.8 (min =18-max=75). When the participants were assessed with regard to antibody positivity and negativity, sedimentation, CRP, NLR, MLR, PLR, eosinophil percentage, eosinophil count, basophil count, basophil percentage, mean platelet volume (MPV), it was seen that there was no statistically significant difference between the values. While there was a weak positive correlation between TSH and anti-TPO and anti-TG, there was a weak and significant positive correlation between the proportions of eosinophils and both anti-TG and anti-TPO. Conclusion: No significant difference has been found in hematological systemic inflammation parameters between euthyroid patients with positive and negative thyroid autoantibodies. In addition, a positive correlation was observed between the percentage and count of eosinophils and thyroid autoantibodies levels