Dataset - The cGAS-STING pathway drives type I IFN immunopathology in COVID-19

Dataset corresponding to the LoC studies in the manuscript titled The cGAS-STING pathway drives type I IFN immunopathology in COVID-19. The following data are included: BioEM.zip: Volumetric electron microscopy - representative movies of volumetric scans of fields of view of the vascular face of uninfected control and SARS-CoV-2 infected LoCs. Blender file containing reconstruction of mitochondria. Cleaved-caspase3.zip: Imaris files for analysis of 3D stacks from two- and three-component LoCs immunostained for cleaved-caspase 3. IFN beta.zip: Imaris files for analysis of 3D stacks from two- and three-component LoCs immunostained for IFN beta. PhosphoSTING.zip: Imaris files for analysis of 3D stacks from two component LoCs immunostained for phosphoSTING. Proteomics_R_code.Rmd: Annotated custom scripts in R for the analysis of the proteomics data.VVT received support from a grant from the Novartis Foundation for Medical-Biological Research (grant no: 20C240)