The overall structure of microbiota in patients with adenocarcinoma stomach and colon cancer

Movchan O. V. The overall structure of microbiota in patients with adenocarcinoma stomach and colon cancer. Journal of Education, Health and Sport. 2020;10(5):357-365. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.05.038 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.05.038 https://zenodo.org/record/4437107 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 04.05.2020. Revised: 16.05.2020. Accepted: 29.05.2020. The overall structure of microbiota in patients with adenocarcinoma stomach and colon cancer O. V. Movchan Kharkiv Institute for medical Radiology and Oncology named V.G.Grigoriev NAMS of Ukraine, Kharkiv, Ukraine Abstract Introduction Accumulating evidence suggests that the human bowel microbiota contributes to the etiology of colorectal cancer (CRC) and stomach cancer, not only via the pro-carcinogenic activities of specific pathogens but also via the influence of the wider microbial community, particularly its metabolome. The aim of the study The aim of this study was to analyzes the overall structure of microbiota in patients with adenocarcinoma of colorectal and the stomach and healthy controls. Results The studies suggested that colorectal cancer and stomach cancer develops from the complex interactions between inherited susceptibility and environmental factors, there a strong association between adenomatous polyps and some pathogenic bacteria are the precursors of the vast majority of colorectal cancers and stomach. Thus, the data suggested the development of intestinal dysbiosis in patients with adenocarcinoma, which was characterized by inhibiting obligate protective microflora and activation opportunistic microorganisms on the base of carbohydrates, fats, and proteins metabolism disturbances and accumulation of toxic metabolic products that may be an important pathogenetic factor of tumor tissue activation, induction, proliferation, and metaplasia. Significant accumulation of biogenic amines (methylamine, serotonin, histamine) is a leading metabolic profile of microflora inpatient with adenocarcinoma and may have a predictive value for diagnosis, pathogenetic therapy, and determination of food nutrients role in the mechanisms of cancer formation, as well as identifying populations of cancer risk. Conclusions The composition of the tumor microbiome differed from that of adjacent non-neoplastic tissue. The subsite-specific alterations in the colorectal carcinoma and stomach cancer microbiota. There is a high incidence of colorectal cancer and stomach cancer associated with Streptococcus Bovis. These results suggested that the mucosa-associated microbiota is dynamically associated with colorectal carcinoma, which may provide evidence for microbiota-associated diagnostic, prognostic, preventive, and therapeutic strategies for colorectal carcinoma and stomach cancer. Key words: microbiota; tumor tissue activation; colorectal carcinoma and stomach cancer; biogenic amines; Streptococcus Bovis