Systems biology modelling involves the mathematical representation of biological processes to study complex system behaviour and was expected to be less affected by the reproducibility crisis. However, models often fail to reproduce and the reasons for the failure and prevalence were not fully understood. We analyzed 455 kinetic models published in 152 peer-reviewed journals. Most of these models were manually encoded from scratch to assess reproducibility. Our investigation revealed that 49% of the models could not be reproduced using the information provided in the manuscripts. With further effort, an additional 12% could be reproduced either by empirical correction or support from authors. The other 37% remained non-reproducible due to m...
International audienceWith the development of new experimental technologies, biologists are faced wi...
International audienceWith the development of new experimental technologies, biologists are faced wi...
International audienceWith the development of new experimental technologies, biologists are faced wi...
Systems biology modelling involves the mathematical representation of biological processes to study ...
Presentation delivered at the UC Meta Colloquium, November 16-18 2022 Abstract: The Center for Rep...
Most scientific discoveries rely on previous or other findings.<br>A lack of transparency and openne...
Background: The concept of reproducibility is a foundation of the scientific method. With the arriva...
Background: The concept of reproducibility is a foundation of the scientific method. With the arriva...
There are currently no widely shared criteria by which to assess the validity of computational model...
Modelers must restore confidence in Systems and Computational Biology by avoiding over-interpretatio...
Background Dynamic modelling is one of the cornerstones of systems biology. Many research efforts a...
With the development of new experimental technologies, biologists are faced with an avalanche of dat...
Thesis (Ph.D.)--University of Washington, 2019Mathematical models are used widely throughout the sci...
International audienceWith the development of new experimental technologies, biologists are faced wi...
International audienceWith the development of new experimental technologies, biologists are faced wi...
International audienceWith the development of new experimental technologies, biologists are faced wi...
International audienceWith the development of new experimental technologies, biologists are faced wi...
International audienceWith the development of new experimental technologies, biologists are faced wi...
Systems biology modelling involves the mathematical representation of biological processes to study ...
Presentation delivered at the UC Meta Colloquium, November 16-18 2022 Abstract: The Center for Rep...
Most scientific discoveries rely on previous or other findings.<br>A lack of transparency and openne...
Background: The concept of reproducibility is a foundation of the scientific method. With the arriva...
Background: The concept of reproducibility is a foundation of the scientific method. With the arriva...
There are currently no widely shared criteria by which to assess the validity of computational model...
Modelers must restore confidence in Systems and Computational Biology by avoiding over-interpretatio...
Background Dynamic modelling is one of the cornerstones of systems biology. Many research efforts a...
With the development of new experimental technologies, biologists are faced with an avalanche of dat...
Thesis (Ph.D.)--University of Washington, 2019Mathematical models are used widely throughout the sci...
International audienceWith the development of new experimental technologies, biologists are faced wi...
International audienceWith the development of new experimental technologies, biologists are faced wi...
International audienceWith the development of new experimental technologies, biologists are faced wi...
International audienceWith the development of new experimental technologies, biologists are faced wi...
International audienceWith the development of new experimental technologies, biologists are faced wi...