Clinical Significance of Hilar Hyalinosis in Glomeruli of Children with Idiopathic Nephrotic Syndrome

Introduction: Hilar hyalinosis (HH) of glomeruli has been thought for a long time to be a precursor or a variant of focal glomerulosclerosis (FGS). In view of its implications on treatment and prognosis of nephrotic syndrome, a retrospective study of hilar hyalinosis in children with the idiopathic nephrotic syndrome (INS), but without any other histologic evidence of FGS, was performed to determine the clinic-pathologic significance of this lesion. Methods: A total of 92 Children with INS who had kidney biopsies for frequent relapses, steroid dependency or resistance were included. Eight of them had a biopsy-proven diagnosis of either minimal change disease or mild IgM nephropathy with HH in 6-25% of glomeruli were compared to control group consisting of 84 children with either minimal change disease (n=57) or IgM nephropathy (n=27) but without HH