FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF CAPTOPRIL

The present investigation concerns the development of Sustained release matrix tablets of Captopril, which after oral administration are designed to prolong the duration up to 12 hrs and thereby increase patient compliance, reduced frequency of administration and increase therapeutic efficacy. Ten batches of tablets were fabricated containing Captopril, polymers HPMC K100M, ethyl cellulose, sodium CMC and other excipients. All the batches were formulated by direct compression. The evaluation was done on the granules which include compressibility, flow property. The tablets were evaluated for appearance, thickness, hardness, assay, weight variation, friability, and in vitro release studies. The results obtained were satisfactory and complies with the Pharmacopoeial specifications. The formulation containing HPMC K100M and ethyl cellulose (F7) showed slower release as compare to other formulations. The in-vitro release data was treated with mathematical equations. Thus the combination of HPMC K100M and ethyl cellulose (1:1) shows satisfactory retarding release of Captopril from matrix to 12 hrs