Development and Formulation of an Antibacterial Gel Containing Eucalyptus and Peppermint Oil

Abstract: This study aimed to develop and formulate an antibacterial gel with eucalyptus and peppermint oil, with the purpose of evaluating the physical and chemical characteristics of five different formulations. Formulations (F1, F2, F3, F4 and F5) were evaluated for pH, spreadability, homogeneity, extrudability, viscosity and in vitro drug release. Additionally, an assessment of bacterial growth inhibition was made. Results revealed that all formulations had a pH range from 6.5 to 6.8, spreadability range of 2.2 to 3.4 cm, extrudability range of 84.25 to 86.14% and viscosity range between 1250±1.2 to 1271±1.2 cps. The in vitro drug release profiles of the formulations were dependent on the polymer type used. Furthermore, all formulations demonstrated significant antibacterial activity against Escherichia coli and Staphylococcus aureus in in vitro assays. Overall, this study provides valuable insight into creating an effective antibacterial gel using natural plant-based ingredients