INCIDENCE OF IRREGULAR PARATHYROID HORMONE IN PATIENTS OF RENAL FAILURE PLANNED TO UNDERGO HEMODIALYSIS

Objective: To define the frequency distribution of abnormal parathyroid hormone in patients of renal failure planned to undergo hemodialysis, at a tertiary care center. Study Design: Single center, cross sectional study Place and Duration of Study: This study was conducted at the Department of Nephrology, Mayo Hospital Lahore from August 2019 to July 2020. Materials and Methods: There were 90 patients with diagnosis of CRF planned to undergo hemodialysis included. Before dialysis blood sample was obtained and sent to the laboratory of the hospital for assessment of PTH level. Then patients underwent hemodialysis. Dialysis was done as per hospital protocol. All the data was collected using the proforma. Results: Patients` mean age was computed to be 53.79±6.51 years. Frequency of abnormal parathyroid was observed in 71.11% (64/90), in which hypoparathyroidism was 44.44% (40/90) and 26.67% (24/90) had hyperparathyroidism. Conclusion: We found high frequency of abnormal parathyroid hormone in patients of renal failure planned to undergo hemodialysis. Derangement of Parathyroid hormone is progressive and it prevalence is found in the patients with chronic kidney disease (CKD) and with serious outcomes for the health of patients. If it is poorly overcome, this imbalance can result in the bone disease, calcification of soft tissue and vascular calcification, all of these are found to be influential on mortality and morbidity. Key Words: Chronic Kidney Disease, Hemodialysis, Hypoparathyroidism, Hyperparathyroidism