Aliskiren: analytical review for estimation in pharmaceutical formulations

Aliskiren (AL) is classified as angiotensin converting enzyme inhibitors (ACEIs) used as antihypertensive drug it acts by dilating blood vessel. These dilation of blood vessel caused due to the renin inhibition. There have been numerous methods developed so far for quantitative estimation of AL in bulk and pharmaceutical dosage form. Pharmaceutical analytical methods include UV Visible Spectrophotometry, Reversed Phase High Performance Liquid Chromatography and hyphenated techniques like Liquid chromatography- Mass Spectrometry. This review paper includes various publications focuses on advanced analytical methods. The chromatographic methods primarily RP-HPLC and LC-MS found more promising and sensitive compared to other pharmaceutical methods