Condition of pro-oxidant and antioxidant systems in guinea pigs' lungs under the condition of immobilization stress

Kryvko Yurij, Soguiko Yurij, Hot Iryna, Antonenko Yuliia, Baida Mariana, Kovalska Marta. Condition of pro-oxidant and antioxidant systems in guinea pigs’ lungs under the condition of immobilization stress. Journal of Education, Health and Sport. 2021;11(05): 319-324. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.05.033 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.05.033 https://zenodo.org/record/5559664 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.05.2021. Revised: 21.05.2021. Accepted: 28.05.2021. UDC: 616.24-002-008.6-056.3-092: 612.24.015.11 сondition of pro-oxidant and antioxidant systems in guinea pigs’ lungs under the condition of immobilization stress Yurij Kryvko1, Yurij Soguiko1, Iryna Hot¹, Yuliia Antonenko¹, Mariana Baida, Marta Kovalska Danylo Halytsky Lviv National Medical University, Lviv 1Andrei Krupynskyi Lviv Medical Academy, Lviv dr.kowalska.marta@gmail.com Abstract We have investigated the results of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde) and antioxidant (superoxide dismutase, ceruloplasmin, catalase) systems in guinea pigs’ lungs under the conditions of immobilization stress. The experiment was conducted on 40 female guinea pigs weighing 0.18-0.20 kg. The animals were divided into 4 groups, each contained 10 guinea pigs: I – intact guinea pigs (control), II–guinea pigs with model of IS on1st day of experiment;Ш–animals on 2nd day of experiment;IV- group of animals on 34th day of experimental model of IS. The results of our experimental work showed a significant accumulation of lipid peroxidation products in the lung`s tissure in different periods (on 1st, 2nd and 34th days) of immobilization stress. The state of antioxidant defence was characterized by moderate decrease of inzymes activity (superoxide dismutase, catalase and ceruloplasmin). disorders of balance between pro-oxidant and antioxidant systems couse oxidative stress development. Key words: immobilization stress; peroxide lipid oxidation; antioxidant system