Korean Colorectal Cancer Cohort RNA-seq data set from Samsung Medical Center

As one of the diseases bearing the highest mortality rates, colorectal cancer (CRC) highlights the importance of comprehending its molecular mechanisms to develop effective therapies. In this paper, we conducted RNA sequencing (RNA-seq) analysis on a combined total of 476 samples consisting of normal colon tissues and colorectal cancer tissues. These samples were obtained from Samsung Medical Center in South Korea which included fresh-frozen CRC tissues as well as adjacent normal tissues. By analyzing gene expression differences, we identified that upregulated genes in tumor tissues were significantly associated with pathways related to the cell cycle and ECM-receptor interaction. Conversely, genes exhibiting high expression in normal tissues were primarily enriched in metabolic pathways. Furthermore, we examined the biological difference between early and late clinical stages of CRC. These findings provide valuable insights into the molecular mechanisms underlying CRC in Korean patients and suggest potential targets for novel treatments. To facilitate further exploration, all the materials utilized in generating the results presented in this paper, including raw files and processed data, have been deposited in a public repository.As one of the diseases bearing the highest mortality rates, colorectal cancer (CRC) highlights the importance of comprehending its molecular mechanisms to develop effective therapies. In this paper, we conducted RNA sequencing (RNA-seq) analysis on a combined total of 476 samples consisting of normal colon tissues and colorectal cancer tissues. These samples were obtained from Samsung Medical Center in South Korea which included fresh-frozen CRC tissues as well as adjacent normal tissues. By analyzing gene expression differences, we identified that upregulated genes in tumor tissues were significantly associated with pathways related to the cell cycle and ECM-receptor interaction. Conversely, genes exhibiting high expression in normal tissues were primarily enriched in metabolic pathways. Furthermore, we examined the biological difference between early and late clinical stages of CRC. These findings provide valuable insights into the molecular mechanisms underlying CRC in Korean patients and suggest potential targets for novel treatments. To facilitate further exploration, all the materials utilized in generating the results presented in this paper, including raw files and processed data, have been deposited in a public repository