Microwave-mediated Green synthesis of oxadiazole derivatives against inflammatory disease

Department of Pharmacy, Vikas Group of Institution, Nunna-521 212, Vijayawada Rural, Andhra Pradesh, India E-mail: drbiswamohansahoo@gmail.com Department of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, Berhampur-760 010, Odisha, India Community Health System of South Texas, Edinburg, Texas 78539, USA Manuscript received 30 September 2018, accepted 01 November 2018 A rapid and efficient microwave-mediated Green synthesis of oxadiazole derivatives (2a-e) is described based on reaction between benzohydrazide and various substituted benzoic acids. The use of microwave irradiation to carry out chemical reac­tions provides pollution free and eco-friendly system with formation of pure products. The structural elucidation of newly syn­thesized compounds is based on their spectral data such as IR and 1H NMR. The titled compounds are screened for their anti-inflammatory activity. Some of the compounds displayed significant anti-inflammatory activity than the standard drug