Dynamics of antioxidant-prooxidant balance in abdominal injury with underlying hypovolemic shock and reperfusion syndrom of the limbs in experiment

Krylyuk V. O., Grodetskyi V. K., Fedoseyeva O. V., Garian S. V. Dynamics of antioxidant-prooxidant balance in abdominal injury with underlying hypovolemic shock and reperfusion syndrom of the limbs in experiment. Journal of Education, Health and Sport. 2020;10(1):113-127. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.01.013 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.01.013 http://dx.doi.org/10.5281/zenodo.3630627 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 20.12.2019. Revised: 25.12.2019. Accepted: 29.01.2020. UDC 617.553-001.36-005.1-06:617.58:577.12 DYNAMICS OF ANTIOXIDANT-PROOXIDANT BALANCE IN ABDOMINAL INJURY WITH UNDERLYING HYPOVOLEMIC SHOCK AND REPERFUSION SYNDROM OF THE LIMBS IN EXPERIMENT V. O. Krylyuk1, V. K. Grodetskyi2, O. V. Fedoseyeva3, S. V. Garian4 1GO «Ukrainian Scientific and Practical Center of Emergency and Disaster Medicine Ministry of Health of Ukraine» 2Higher State Educational Establishment of Ukraine «Bukovinian State Medical University» 3Cherkasy Medical Academy, 4I. Ya. Gorbachevskiy Ternopil State Medical University Abstract The article describes the results of the experimental study in which the effect of ischemic-reperfusion limb syndrome on changes in the internal organs was studied. Changes in the values of Malone dialdehalide, superoxide dismutase and catalase in the tissues of the kidneys, liver, lungs and muscles of the extremities were studied. These studies confirmed the hypothesis and proved the presence of signs of systemic changes as a result of applying a hemostatic tourniquet, the presence of potentiating effects of reperfusion syndrome with a combined injury of the abdominal cavity against the ground of hypovolemic shock. Key words: trauma; abdominal cavity; bleeding; experiment; reperfusion