SYNTHESIS OF TRANSITION METAL ION COMPLEX OF 2-AMINOBENZOXAZOLE AND ANTIFUNGAL ACTIVITY AND ROLE IN PHARMACEUTICAL CHEMISTRY

In view of the fact that a large number of derivatives of benzoxazole have been found to exhibit a wide variety of antimicrobial activities. Heterocyclic compounds play an important role in medicinal chemistry and exhibit wide range of biological activities in pharmaceutical chemistry. Complexes of 2-aminobenzoxazole (L) with chloride of iron (II), was synthesized. The molar ratio metal: ligand in the reaction of the complex formation was 1:2. It should be noticed, that the reaction of all the metal salts yielded bis (ligand) complex of the general formula M (L) 2(CL) 2. The complex was characterized by elemental analysis, melting point, FT-IR, 1H NMR, spectral data. The antifungal activity against different fungai, A.niger, A.flavus, Fusarium oxysporum, paecilomyces variotii, C.albicans