Synthesis and biological significance of 2-mercaptobenzoxazole derivatives

Synthetic Organic Chemistry Laboratory, Department of Chemistry, Dr. H. S. Gour University, Sagar-470 003, Madhya Pradesh, India E-mail : ayush_ ashu2005@yahoo.co.in Manuscript received 20 December 2005, revised 2 August 2006, accepted 23 August 2006 Several 2-aryl-3-[(2-mercaptobenzoxazolo)acetamidyl]-4-oxothiazolidines 4, and 2-aryl-3-[(2- mercaptobenzoxazolo)acetamldyl]-5-arylidene-4-oxothiazolidines 5 have been synthesized by the appropriate methods and evaluated for their antibacterial activity against \(Escherichia\) \(coli\), \(Shigella\) \(dysenteriae\),\(Streptococcus\) \(aureus\) and \(Salmonella\) \(typhimurium\); antifungal activity against \(Aspergillus\) \(niger,\)\(Candida\) \(albicans\),\(Fusarium\) \(heterosporium\) and \(Rizopus\) \(oryzae\) and antiinflammatory activity against the carrageenan induced rat paw oedema method in albino rats. In the primary screening some of· the products displayed acceptable Biological activity. The structure of the synthesized com·pounds has been established on the basis of their spectral and microanalytical data