ESTIMATION OF LIPOPHILICITY OF SOME ALCOHOLS USING TOPOLOGICAL INDICES QSAR STUDIES

In This paper, I used different topological indices for modeling of lipophilicity of a series of alcohols. A wide variety of indices like the Weiner(W), The Padmakar Iwan (PI) index, Kier and Hall valence connectivity indices , Randic connectivity indices and Balaban and Balaban type indices were used for obtaining statistically significant model. The statistically significant models are governed by a variety of statistical parameters .The regression analysis has shown that out of pool of topological indices used, the topological indices W and PI in combination with connectivity indices given an excellent result. The results indicate that lipophilicity of given series of alcohols can be successfully modeled by using topological indices W and PI in combination with connectivity indices as correlating parameters