Toxicological evaluation of co-exposure to microplastics and benzo(a)pyrene on a 3D human bronchial epithelium model

Airborne microplastics (MPs) have been recently detected in human lung tissue, but their fate and impact on airways is still unrevealed. Our study focuses on the impacts of polyethylene terephthalate(PET) or polystyrene (PS) alone or combined with BaP on an in vitro model of human bronchial epithelium that we recently developed to study short and long-term effects, on air-liquid interface (ALI) grown Calu-3 cell line (lung adenocarcinoma patient cells)