Chemiluminescence as a diagnostic aid in the detection of oral cancer and potentially malignant epithelial lesions

Chemiluminescence was evaluated as a diagnostic aid in the detection of oral cancer and potentially malignant epithelial lesions (PMELs) by comparing it against 1 tolonium chloride mouth rinse. Forty-six clinically identified lesions 14 primary squamous cell carcinoma (SCC), 26 PMELs and 6 benign lesions and five cases of normal oral mucosa from 40 subjects (inclusive of 10 previously treated SCC cases) were examined with a commercial chemiluminescent kit (Vizilite (R)) and tolonium chloride. Biopsy and histological verification of 31 lesions disclosed 14 SCC (45.2%), 10 epithelial dysplasias (32.3%), 5 lichen planus (16.1%) and 2 benign lesions (6.4%). For the remaining 15 lesions, a biopsy was not performed owing to patient's lack of consent or ill-health. The five cases of normal oral mucosa which tested negative for both tools were also not biopsied for ethical reasons. Sensitivity for Vizilite (R) and tolonium chloride was 100% and 70.3%, respectively; and specificity was 14.2% for Vizilite (R) and 25% for tolonium chloride. Their accuracy was 80.6% and 64.5%, respectively. Current findings suggest that chemiluminescence is a more reliable diagnostic tool than tolonium chloride in the detection of oral cancer and PMELs, and for follow-up of patients treated for the same. This record was migrated from the OpenDepot repository service in June, 2017 before shutting down