A REVIEW ARTICLE ON ROLLER COMPACTION

In pharmaceutical oral solid dosage forms we have been widely used for decades which are mainly depend on their convenience of administration with suitability drug delivery for its systemic effects. Granules, pellets, tablets and capsules are commonly used in pharmaceutical solid dosage forms. As the solid pharmaceutical dosage forms which mainly containing the drug substances with or without suitable diluents were prepared by either compression or molding methods that is define as tablet. Direct compression, wet granulation and dry granulation are the three basic tableting methods. If the materials have sufficient inherent binding or cohesive properties to form granules dry granulation may be used. The process of granulating without the use of liquids it may refer as a dry granulation. Slugging and roll compaction are the two dry granulation methods which are used in the pharmaceutical industry. Particles which are consolidated and dignified by passing the material between two high pressure rollers are in the roll compactor. Reduced form to the uniform granule size by milling is used by the dignified material from roller compactor. Chemically moisture or physically moisture sensitive drugs are processing for choice of method with (RC/DG) Roll compaction/dry granulation and which has no liquid binder required in the granulation. This literature review illustrates the progress and the use of RCDG in the production of directly compressible excipients, the compaction of drugs and drug formulations. Keywords: Roll compaction, Dry granulation, Tablets, Excipients, Herbal dry extracts, immediate release, Controlled release