STUDY TO KNOW PATHOGENS CAUSING NEONATAL SEPTICEMIA AND ITS MICROBIAL SENSITIVITY

Objective: To know the most common organisms causing neonatal septicemia and its antimicrobial sensitivity in Neonatal Intensive Care Unit of People’s Medical College Hospital, Nawabshah. Study Design: A prospective descriptive study. Place and Duration: In the Pediatrics Department of People’s Medical College Hospital, Nawabshah for one year period from March 2017 to March 2018. Methodology: Into two groups the patients were divided with septicemia in early and late onset. Results: 328 infants from 2487 cases with an infection frequency of 13.5% had positive blood cultures. E. coli, coagulase negative staphylococci and Klebsiella are the common bacteria causing septicemia. These isolates are more sensitive to amikacin, meropenem, chloramphenicol, vancomycin, ciprofloxacin and 3rd generation cephalosporin. The greater frequency of isolated pathogens were taken with 52.9% infection rate for early-onset sepsis and for late sepsis 84.5%. Conclusion: There is no difference in the coagulase negative staphylococcus prevalence (57.3%), Klebsiella spp, E. coli (10.4%) and septicemia (early onset sepsis and end onset). Meropenem was the most effective antibiotic for gram-negative isolates, while against Gram positive isolates vancomycin is very beneficial. Key Words: Newborn, Septicemia, late-onset sepsis, antimicrobial activity, early sepsis