FORMULATION DEVELOPMENT AND INVITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NATEGLINIDE BY USING NATURAL POLYMERS

For treating diabetes, it has been considered important that both a post prandial blood glucose level and a fasting blood glucose level are decreased to make them to normal levels. Nateglinide [N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine] is a novel mealtime glucose regulator approved for the treatment of type II diabetes mellitus. Once a day sustained release matrix tablets of nateglinide was prepared by using natural polymers k-carrageenan,lambda carrageenan and locust bean gum. Natural polymers were selected due to their easy availability and cheaper in coast and we can get standard uniformity and combinations of two different gums carrageenan and locust been gum were formulated in different ratios to exploit the rheological synergism between two gums in order to achive once a day matrix tablets of nateglinide further formulations were prepared from the formulations exhibited maximum retardation the controlled or sustained release formulations of nateglinide would be more useful than the nateglinide immediate release tablets from the new point of side effects improvement of compliance to patients and to enable to control of both post prandial blood glucose level and fasting blood glucose level for moderate and sever diabates patients. Hence an attempt was made to develop a sustained release oral dosage form of nateglinide instead of immediate release tablet. Keywords: Nateglinide, Matrix Tablets, Sustained Release, Natural Polymers