A REVIEW ON THE CURRENT TRENDS IN THE RECENT DEVELOPMENT OF HPLC/UHPLC/UPLC METHODS FOR THE EVALUATION OF VARIENT IMPURITIES IN VARIOUS PHARMACEUTICAL DRUGS

New chromatography technology for the analytical laboratory is being driven by the ever expanding need and challenge to get more and better information faster, all in an economic climate where cost control is a primary concern. At the same time, samples have become more and more complex, detection limits are being driven increasingly lower, and regulatory concerns, particularly for biotherapeutics, are being increasingly scrutinized. To answer today's challenges in the laboratory, chromatographers are taking advantage of available new technology, often in rather unique ways. To tackle a particular issue they sometimes simply apply a new approach to a problem, like a new type of column or detector, or other times use a combination of new technologies, where the end result is greater than the sum of the individual parts. From new columns and detectors to multidimensional and orthogonal applications of technology, chromatographers have an ever expanding repertoire of tools available. Keywords: Pharmaceutical drugs, chromatography, analytical laboratory, HPLC, UPLC, UHPLC