DEVELOPMENT OF COLON TARGETED SUSTAINED RELEASE MATRIX TABLETS OF PREDNISOLONE

ABSTARCT In the present research work sustained release matrix formulation of prednisolone targeted to colon by using various polymers developed. Various eudragit polymers were employed as polymers. Prednisolone dose was fixed as 20 mg. Total weight of the tablet was considered as 300 mg. Polymers were used in the concentration of 30, 60 and 90 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F7) showed better and desired drug release pattern i.e., 98.78 % in 10 hours. It contains the eudragit polymer Prednisolone as sustained release material. It followed zero order release kinetics mechanism. KEYWORDS: Prednisolone, Colon targeted drug delivery system, Ethyl cellulose, Eudragit L100, Eudragit S 100