FORMULATION AND CHARACTERISATION OF ORAL DISINTEGRATING TABLETS OF LAMOTRIGINE USING NOVEL SUPER DISINTEGRANTS

Orally disintegrating tablets are a vital tool in keeping our children and elderly population healthy. Their ease of use and accurate dosing allow higher patient compliance and more reliable therapeutic effects. Superdisintegrants are the fundamental element contained in orally disintegrating tablets and are responsible for their unique ability to quickly disintegrate and dissolve on the surface of the tongue without the use of any additional liquid. In order to determine the most effective type and optimal amount of superdisintegrants for orally disintegrating tablets manufactured by direct compression, the following tablet parameters were tested hardness, thickness, friability, disintegration time, and wetting time. three superdisintegrants were tested, namely: Solutab, Polyplasdone XL and Locust bean gum and the most efficient superdisintegrant was selected based on the above mentioned studies. From the results obtained, it can be concluded that the tablet formulation (F3) showed the promising formulation also the hardness, friability, disintegration time and dissolution rate of prepared tablets were found to be acceptable according to standard limits. Key words: Lamotrigine, Solutab, Polyplasdone XL, Locust bean gum and Mouth dissolving tablets