A CROSS-SECTIONAL STUDY TO OUTLINE RESISTANCE AND SENSITIVITY OF ANTIBIOTIC MEDICINES IN SALMONELLA TYPHI ISOLATES OF ENTERIC FEVER

Objective: The aim of our study was to outline resistance and sensitivity of antibiotic medicines amongst Salmonella typhi isolates of enteric fever in kids. Study Design: Cross-Sectional Study. Place and Duration: This study was carried out for a time period of one year starting from January, 2018 to December, 2018 in Pediatric Medicine Department of District Headquarters Hospital, Rawalpindi. Methodology: Those children who were having enteric fever were selected for the study and in a total quantity of 161. Blood samples 3ml to 5ml were taken from all subjects and instantly sent to the Microbiology laboratory for blood sensitivity and culture tests. Modified Kirby baur disc diffusion on Salmonella isolates on Mueller Hinton agar plates method was used for calculating zone’s width of reserve of certain medicine, Which afterwards, used for defining the antibiotic drug resistance. Clinically examined the pain abdomen, anorexia and coated tongue. SPSS-20 was used for analysis of all collected data. Results: Male and female distribution among 161 selected children were as 91 (56.5%) and 70 (43.5%) respectively. With minimum and maximum age as 2 years and 12 years accordingly, in this study the mean age of patients was 5.79±2.451 years. In 93 (57.8%) cases of our study found usage history of antibiotics before 02 days of the sensitivity and culture test. Most patients of current study were having enteric fever along with abdominal pain 40.37% (65),headache 17.39% (28) and diarrhea 17.39% (28).Sensitivity of Ciprofloxacin found in 54.66% (88),Amoxicillin found in 22.36% (36), Gentamycin found in 17.39% (28), Ofloxacin found in 62.73% (101), Chloramphenicol found in 24.84% (40), Ampicillin found in 12.42% (20), Co-trimoxazole found in 12.42% (20). Conclusion: According to the findings of our study it was found that Salmonella-typhi isolates of enteric-fever presented antibiotic medicine resistance at greater degree. Multidrug resistant strains were found extra predominant in this study that indicates to well-focused efforts of our health plan’s makers to implement positive strategies about usage of antibiotic medicines in population of Pakistan. Keywords: Children, Enteric Fever, Drug Resistance, Antibiotic