A STUDY ON PREVALANCE OF H. PYLORI INFECTION IN GASTRODUODENAL PERFORATION.

1 Dr Nemish V Donda (SMIMER Medical College) Junior Resident (General Surgery)- GMERS Medical College, Valsad-396001, India. Ex. Medical Officer, SMIMER, Surat, 395010, India. 2 Dr Anil Patoliya (Department of General Surgery) GMERS Medical College, Valsad-396001, Valsad, India. 3 Dr Harmik H Maniya* (SMIMER Medical College) Medical Officer- Arham Hospital & ICU, Surat-395009, India. Ex. Medical Officer, SMIMER, Surat, 395010, India. 4 Dr Rutaben D Karkar (SMIMER Medical College) Medical Officer-Surat Municipal Corporation, Surat-395009, India. Ex. Medical Officer, SMIMER, Surat, 395010, India. 5 Dr Rusitkumar M Karkar SMIMER Medical College) Junior Resident (General Surgery)- GMERS Medical College, Valsad-396001, Valsad, India. Ex. Medical Officer, SMIMER, Surat, 395010, India. Abstract Background: - Most patients with chronic peptic ulcer disease have Helicobacter pylori (H. pylori) infection. The incidence of perforated peptic ulcer (PPU) has only declined minimally despite the widespread use of Helicobacter pylori (H. pylori) eradicative agents. Hence the current study was conducted to assess the prevalence of H. pylori infection and other factor like NSAIDS, alcohol, smoking, level of education and economic condition in the patients of gastroduodenal perforation admitted in GMERS Medical College Hospital, Valsad. Methods: - It was a cross sectional hospital based analytical study conducted among 100 patients over the span of 2 years from October 2020 to December 2022, who were diagnosed to have gastroduodenal perforation and who underwent surgical treatment for it. All the details of history, investigation and H. pylori status recorded in the standard, semi-structured, pre-validated case record proforma which is prepared by surgical department Results: -It is observed that the proportion of H. Pylori positive was significantly more in those who were not on NSAID’s compared to those who were on NSAID’s medication. The p-value turns out to be significant at 5% which means that there is an association between NSAID’s and H. Pylori infection. Conclusion: - It is noted that 46(69%) patients were found to be H. Pylori positive. It is observed that the proportion of H. Pylori positive was significantly more in those who were not on NSAID’s compared to those who were on NSAID’s medication. KEYWORDS: GERD, H Pylori, Peptic ulcer disease, gastroduodenal perforatio