TO DETERMINE THE HISTOLOGICAL, CLINICAL AND ENDOSCOPIC FEATURES OF CELIAC DISEASE

Objective: To know the common clinical presentation, endoscopic and histological profile of celiac disease. Study Design: A cross sectional study. Methods: Fifty histologically proven patients with suspected celiac disease were included in the study. Place and Duration: In the Gastroenterology Department of Jinnah Hospital Lahore for one-year duration from May 2018 to May 2019. Results: Twenty-five (48.1%) were male and female were 27 (51.9%). The 20.19 ± 10.68 years was the mean age. 43 (82.7%) patients had chronic diarrhea, 39 (75%) iron deficiency anemia, 34 (65.4%) weight loss, 17 (32.7%) abdominal pain, lack of growth in 15 (%) 28.8) and 15 (28.8%) patients were short stature. Abdominal distension in 13 (25.0%) cases, 8 (15.4%) patient of vomiting, 4 (7.7%) subjects of infertility, 7 (13.5%) subjects of delayed puberty, dermatitis herpetiformis in 1 (1.9%) cases were noted. Atrophic mucosa with mosaic in 20 (38.5%) cases, scalloped nodular mucosa in 15 (28.8%), atrophic nodular mucosa without comb in 6 (11.5%), normal mucosa in 6 (11.5%) 5 Duodenum folding cases and combs. Conclusion: Celiac disease is gluten-sensitive enteropathy in both genders in all age groups with various bowel and extra bowel symptoms. Keywords: Celiac disease, Intestine, Extra bowel, Endoscopic, Histological profile