Diabetic Cardiomyopathy Pathophysiology and Update on Treatment

The presence of diabetes in HF patients portends worse prognosis than does HF without DM. Heart failure in diabetes mellitus (DM) in the absence of conventional risk factors such as hypertension, coronary artery disease (CAD), and congenital or valvular heart disease, has been defined in the literature as diabetic cardiomyopathy (DCM). The question what are the link between DM and DCM? The answer of this question is not well understood. This review will identify the link between diabetes mellitus and DCM, will also explore the possible mechanisms and triggering factors or associations with emphasis upon the implications of new anti-diabetic treatment on preventing development of heart failure in DM. The keywords used in the literature search were heart failure, diabetes mellitus, cardiovascular disease in DM, diabetic cardiomyopathy and treatment of diabetes with heart failure. These keywords were synced into midline and google search to acquire literature reviews and structured topics in order to deliver significant understanding of the mechanism and factors contributing to the development of DCM. All heart failure secondary to known etiology such as hypertension, valvuler heart disease, coronary artery disease or cardio-myopathy without diabetes mellitus excluded. This literature review identify several link between diabetes mellitus and heart failure in the absence of conventional risk factors (DCM), it also explore the possible mechanisms and triggering factors or associations with emphasis upon the implications of new anti-diabetic treatment on preventing development of heart failure in diabetic patients. It also give conception on what remedy can change the course of this disease. DCMhas a distinct substrate in DM patients with HF in the absence of known causes ofheart diseases and its factors. All proven evidence-based medicine for its treatment should be taken into consideration. Uses of new anti-diabetic medication may delay or prevent development of DCM. Further clinical studies and basic science advancement will recognize the context of DCM