RECENT ADVANCES IN TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS): AN OVERVIEW

ABSTRACT Conventional dosage form has significant setbacks of poor bioavailability and frequent dosing due to hepatic first pass metabolism. Transdermal drug delivery systems (TDDS), dosage forms designed to deliver a therapeutically effective amount of drug across a patient’s skin. It is (TDDS) also known as “patches,” are. In order to deliver therapeutic agents through the human skin for systemic effects, the comprehensive morphological, biophysical and physicochemical properties of the skin are to be considered. Transdermal delivery provides a leading edge over injectable and oral routes by increasing patient compliance and avoiding first pass metabolism respectively. Transdermal delivery not only provides controlled, constant administration of the drug, but also allows continuous input of drugs with short biological half-lives and eliminates pulsed entry into systemic circulation, which often causes undesirable side effects. The TDDS review articles provide valuable information regarding the transdermal drug delivery systems and its evaluation process details as a ready reference for the research scientist who is involved in TDDS. KEYWORDS: Transdermal drug delivery systems (TDDS), Topical drug delivery, Hepatic first pass metabolism, therapeutic efficacy, Patches