Seasonal influenza virus infections cause 290,000-650,000 deaths annually and severe morbidity in 3-5 million people. CD8+ T-cell responses towards virus-derived peptide/human leukocyte antigen (HLA) complexes provide the broadest cross-reactive immunity against human influenza viruses. Several universally-conserved CD8+ T-cell specificities that elicit prominent responses against human influenza A viruses (IAVs) have been identified. These include HLA-A*02:01-M158-66 (A2/M158), HLA-A*03:01-NP265-273, HLA-B*08:01-NP225-233, HLA-B*18:01-NP219-226, HLA-B*27:05-NP383-391 and HLA‑B*57:01-NP199-207. The immunodominance hierarchies across these universal CD8+ T-cell epitopes were however unknown. Here, we probed immunodominance status of influenz...
The repertoire of human cytotoxic T-lymphocytes (CTL) in response to influenza A viruses has been sh...
Lack of a universal vaccine against all serotypes of influenza A viruses and recent progress on T ce...
Newly-emerged and vaccine-mismatched influenza A viruses (IAVs) result in a rapid global spread of t...
Seasonal influenza virus infections cause 290,000-650,000 deaths annually and severe morbidity in 3-...
Seasonal influenza virus infections cause 290,000-650,000 deaths annually and severe morbidity in 3-...
Seasonal influenza virus infections cause 290,000-650,000 deaths annually and severe morbidity in 3-...
Although influenza viruses lead to severe illness in high-risk populations, host genetic factors ass...
Miller, A ORCiD: 0000-0001-9735-6609Memory CD8+ T lymphocytes (CTLs) specific for antigenic peptides...
Syngeneic murine systems have pre-fixed MHC, making them an imperfect model for investigating the im...
Although influenza viruses lead to severe illness in high-risk populations, host genetic factors ass...
Although influenza viruses lead to severe illness in high-risk populations, host genetic factors ass...
Memory CD8+ T lymphocytes (CTLs) specific for antigenic peptides derived from internal viral protein...
HLA-A*11:01 is one of the most prevalent human leukocyte antigens (HLAs), especially in East Asian a...
markdownabstractInfluenza viruses are among the leading causes of acute respiratory tract infections...
textabstractThe repertoire of human cytotoxic T-lymphocytes (CTL) in response to influenza A viruses...
The repertoire of human cytotoxic T-lymphocytes (CTL) in response to influenza A viruses has been sh...
Lack of a universal vaccine against all serotypes of influenza A viruses and recent progress on T ce...
Newly-emerged and vaccine-mismatched influenza A viruses (IAVs) result in a rapid global spread of t...
Seasonal influenza virus infections cause 290,000-650,000 deaths annually and severe morbidity in 3-...
Seasonal influenza virus infections cause 290,000-650,000 deaths annually and severe morbidity in 3-...
Seasonal influenza virus infections cause 290,000-650,000 deaths annually and severe morbidity in 3-...
Although influenza viruses lead to severe illness in high-risk populations, host genetic factors ass...
Miller, A ORCiD: 0000-0001-9735-6609Memory CD8+ T lymphocytes (CTLs) specific for antigenic peptides...
Syngeneic murine systems have pre-fixed MHC, making them an imperfect model for investigating the im...
Although influenza viruses lead to severe illness in high-risk populations, host genetic factors ass...
Although influenza viruses lead to severe illness in high-risk populations, host genetic factors ass...
Memory CD8+ T lymphocytes (CTLs) specific for antigenic peptides derived from internal viral protein...
HLA-A*11:01 is one of the most prevalent human leukocyte antigens (HLAs), especially in East Asian a...
markdownabstractInfluenza viruses are among the leading causes of acute respiratory tract infections...
textabstractThe repertoire of human cytotoxic T-lymphocytes (CTL) in response to influenza A viruses...
The repertoire of human cytotoxic T-lymphocytes (CTL) in response to influenza A viruses has been sh...
Lack of a universal vaccine against all serotypes of influenza A viruses and recent progress on T ce...
Newly-emerged and vaccine-mismatched influenza A viruses (IAVs) result in a rapid global spread of t...