Effectiveness Test of Red Betel Leaf Essential Oil Ointment on Wound Healing in Wistar Rats (Rattus Norvegicus)

Abstract: About 350,000 vascular plants (tracheophytes) have the potential to become medicinal plants, but about 10% of them, namely about half a million species, are used as medicinal plants. Red betel leaf is one of the medicinal plants that deserve to be considered as an herbal medicine to replace chemical drugs. This study was designed to determine the effectiveness of ointment from the essential oil of red betel leaves (piper crocatum linn.) in healing wounds in Wistar rats (Rattus norvegicus). This type of research is experimental, with a Pre-test and Post-test group only control design approach conducted from March to November 2022. This research was conducted at Herbarium Medanese FMIPA USU, Pharmacognosy Laboratory of Faculty of Pharmacy USU, and Pharmacology Laboratory of Pharmacy USU. The study sample was 25 white male rats randomly selected, which were divided into five groups (4 treatment groups and one control group) so that one treatment group consisted of 5 rats. Essential Oil Saleb Red Betel Leaf extract (piper crocatum linn.) has several bioactive compounds such as alkaloids, flavonoids, saponins, and tannins that play a role in wound healing. The optimum concentration of Essential Oil Saleb of Red Betel Leaf extract (piper crocatum linn.) that can heal cut wounds in white rats is 6%. The highest percentage of healing on day k-14 was in the positive control (Bioplacenton®), which was 95% and followed by 6% v/v extract with a 90% healing percentage. Essential Oil Saleb preparation of Red Betel Leaf extract (piper crocatum linn.) has an ability that is close to Bioplacenton® in the recovery of cut wounds in rats. Keywords: Red Betel, Essential Oil, Wound Healing. Title: Effectiveness Test of Red Betel Leaf Essential Oil Ointment on Wound Healing in Wistar Rats (Rattus Norvegicus) Author: Xu Haidong International Journal of Life Sciences Research ISSN 2348-313X (Print), ISSN 2348-3148 (online) Vol. 11, Issue 1, January 2023 - March 2023 Page No: 86-91 Research Publish Journals Website: www.researchpublish.com Published Date: 24-March-2023 DOI: https://doi.org/10.5281/zenodo.7766158 Paper Download Link (Source) https://www.researchpublish.com/papers/effectiveness-test-of-red-betel-leaf-essential-oil-ointment-on-wound-healing-in-wistar-rats-rattus-norvegicusInternational Journal of Life Sciences Research, ISSN 2348-313X (Print), ISSN 2348-3148 (online), Research Publish Journals, Website: www.researchpublish.co