FORMULATION AND EVALUATION OF VALSARTAN MICROSPHERES BY IONOTROPIC GELATION TECHNIQUE

In this present research study, an attempt was made to develop valsartan microspheres and consider the influence of various concentrations of sodium alginate and calcium chloride on particle size, entrapment efficiency, and drug release of the same. These microspheres were prepared by ionotropic gelation technique for oral delivery in the treatment of Hypertension. The formulated microspheres were evaluated regarding entrapment efficiency, percentage yield, drug release and characterization was studied using FTIR and SEM analysis. Among the total 14 formulations, S12 formulation was optimized at 2% of sodium alginate, 10% of calcium chloride with pectin. The in vitro dissolution showed sustained release of Valsartan up to 97.89±5.25 by diffusion mechanism over 12h, which followed the zero order and Higuchi model (R2 = 0.990, 0.979) respectively, the drug release from microspheres was anomalous Non fickian diffusion. From these results it was concluded that, optimized formulation is stable and retained their original properties with minor differences. Valsartan alginate microspheres is an effective drug delivery system that offers more predictable and extensive drug release and helps in the treatment of Hypertension. Key Words: Valsartan, Microspheres, Hypertension, Cross-linking agent