ANALYSIS OF STUDY ON THE ROLE OF PARATHYROID HORMONE IN HYPERTENSION AND BLOOD PRESSURE

Introduction: Hypertension is one of the important risk factors for cardiovascular disease, which is the major cause of morbidity and mortality worldwide. In particular, changes in systemic calcium metabolism are thought to play an important role in the regulation of blood pressure. Objectives of the study: The basic aim of the study is to find the role of parathyroid hormone in hypertension and blood pressure. Material and methods: This cross sectional study was conducted at Services Institute of Medical Sciences, Lahore during February 2018 to November 2018. This study was conducted on 100 patients which was suffering from hypertension and visit the OPD of hospital regularly. Venous blood samples were drawn after overnight fasting for the measurement of serum glucose, creatinine and total cholesterol. Serum was also stored at −30°C for measurement of PTH. Serum calcium, phosphorous, and albumin were measured. BP was obtained using an automatic BP monitor. Three measures were taken at rest in a sitting position, with intervals of 5 min between the measurements. The average from the last two measurements was taken for analysis. Results: Calcium and PTH levels significantly decreased in all hypertensive patients with a cure rate of 99.1%. The mean systolic and diastolic BP decreased in the total population of hypertensive patients and hypertensive patients on antihypertensive therapy. Patients with PHPT experienced a significant decrease in both systolic BP (P < .001) and diastolic BP. High BP was present in 34% of the whole sample, and another 16% were taking medication for hypertension. Conclusion: It is concluded that serum vitamin D and PTH levels are not independently associated with blood pressure or risk of hypertension. Hypertension associated with common endocrine conditions which are not classically considered to be etiologies involved in the work up of a patient with suspected secondary hypertensio