INFLUENCE OF ANTIRETROVIRAL THERAPY DURATION HIV RNA SHEDDING IN SEMEN

The semen of an HIV-infected man is the most widely recognized method of HIV transmission. Highly Active Antiretroviral Therapy (HAART) frequently results in an imperceptible blood HIV RNA viral load (VL), and it has been proposed that there might be no danger of sexual transmission in this specific situation. Be that as it may, the effect of viable HAART on HIV levels in semen requires additionally consider. We played out an imminent, longitude semen of an HIV-contaminated man is the most widely recognized method of HIV transmission. Highly Active Antiretroviral Therapy (HAART) regularly results in an imperceptible blood HIV RNA viral load (VL), and it has been proposed that there might be no danger of sexual transmission in this unique situation. Be that as it may, the effect of viable HAART on HIV levels in semen requires additionally think about. We played out a forthcoming, longitudinal investigation of semen and blood HIV RNA levels after HAART commencement and a cross-sectional examination in men on long-haul viable HAART. Compelling HAART was characterized as the accomplishment of an imperceptible blood VL. udinal investigation of semen and blood HIV RNA levels after HAART commencement, and a cross-sectional examination in men on long-haul powerful HAART. Viable HAART was characterized as the accomplishment of an imperceptible blood VL. These findings demonstrate that neither systemic nor mucosal HIV-specific CD8+ responses, when assayed with IFN production as an endpoint, were associated with reduced HIV RNA levels in blood or semen. Semen HIV RNA levels did correlate with local inflammatory cytokines and CMV reactivation. Furthermore, despite effective HAART a significant proportion of HIV-infected men continued to shed HIV RNA in semen