Synthesis of novel 1,2,3-triazole incorporated quinoline derivatives via click chemistry and evaluation of their antimalarial activity

Department of Chemistry, University of Delhi, Delhi-110 007, India E-mail : dsrawat@chemistry.du.ac.in Fax : 91-11-27667501 b National Centre for Natural Products Research, University of Mississippi, Oxford, MS 38677, USA Manuscript received 05 January 2014, accepted 15 January 2014 A series of structurally diverse novel 1,2,3-triazole incorporated quinoline derivatives (7a-g and 8a-l) were prepared via simple and efficient click chemistry involving CuI catalyzed intermolecular Huisgen [3+2] cycloaddition reaction in good to excellent yields. All the synthesized compounds were evaluated for their antimalarial activity against CQ-sensitive (D6 clone) and CQ-resistant (W2-clone) strains of P. falciparum and mammalian cell cytotoxicity against Vero cells in an in vitro assay