LIPID BASED DRUG DELIVERY SYSTEM – A REVIEW

Lipid-based drug delivery systems (LBDDS) have gained significant attention in recent times, owing to their ability to overcome the challenges limiting the oral delivery of poorly water-soluble drugs. Despite the successful commercialization of several LBDDS products over the years, a large discrepancy exists between the number of poorly water-soluble drugs displaying optimal in-vivo performances and the application of LBDDS to mitigate their various delivery challenges. The formation of drugs carried out with the principle objective of enhancing their bioavailability. Poorly water-soluble drugs are challenging for the formulation scientists with regard to solubility and bioavailability. However, the number of applications for lipid-based formulations has expanded as the nature and type of active drugs under investigation have become more varied. This paper mainly focuses on novel lipid-based formulations, namely, emulsions, vesicular systems, and lipid particulate systems and their subcategories as well as on their prominent applications in pharmaceutical drug delivery. Key words: Lipid-based drug delivery systems, poorly water-soluble drugs, in-vivo