STATUS OF THYROID AND PROLACTIN HORMONE LEVELS AMONG PRIMARY INFERTILITY PATIENTS

Objective: Infertility is defined as the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse. Hyperprolactinemia and thyroid dysfunction are associated with reproductive dysfunction and infertility. Hypothyroidism and hyperprolactinemia are found to be closely interrelated. This study aimed to observe the level of serum prolactin, free Tri-iodothyronine (fT3), free Thyroxine (fT4) and Thyroid stimulating hormone (TSH) in women with primary infertility and to correlate the level of serum prolactin with TSH. Methods: The study was conducted on patients visiting OPD because of infertility at the Medicine and Gynecology and Obstetrics department of Services Hospital Lahore for one year duration from May 2019 to May 2020. The study included 50 women with primary infertility and 50 healthy controls of same age. Serum prolactin, fT3, fT4 and TSH levels were measured in all subjects. Results: The mean age of participants was 26.8 years. The median serum prolactin (21.8) and TSH levels (4.5) were found to be significantly high in the case group (p<0.001). Out of the total subjects with hyperprolactinemia, 51.1% were found to have hypothyroidism. There was a moderately strong, positive and significant correlation between serum prolactin and TSH levels (r=0.62, p