THE EFFECT OF AMBON BANANA STEM EXTRACT (MUSA PARADISIACA VAR. SAPIENTUM) AGAINST TUMOR NECROSIS FACTOR ALPHA EXPRESSION (TNF-Α) ON GASTRIC OF RATS (RATTUS NORVEGICUS) INDUCTED BY INDOMETHACIN

The purpose of this research was to prove the role of ambon banana stem (Musa paradisiaca var. sapientum) against inflammation as measured by decreased expression of Tumor Necrosis Factor Alpha (TNF-α) in gastric of rat (Rattus norvegicus). Twenty rats (Rattus norvegicus) with 8-12 week ages and 150-200 g avarage of body weight were divided into five groups (K-, K+, P1, P2 and P3). K- and K+ as control, P1 was treated with ambon banana stem extract dose 200mg/kg BW, P2 was treated with ambon banana stem extract dose 400mg/kg BW, P3 was treated with ambon banana stem extract dose 800/kg BW. This research has been conducted for 13 days. The data of TNF-α expression were analyzed with Kruskal-Wallis and continued with Man-Whitney. Result showed there were significant (p