ANALYSIS OF RELATIONSHIP OF PARATHYROID HORMONE AND HYPERTENSION

Introduction: Numerous studies in humans and experimental models have shown that alterations in calcium homeostasis are associated with an increased risk of cardiovascular complication. In particular, changes in systemic calcium metabolism are thought to play an important role in the regulation of blood pressure. Aims and objectives: The basic aim of the study is to find the relationship between parathyroid hormone and hypertension in local population of Pakistan. Material and methods: This study was conducted at DHQ Hospital, Muzaffargarh during Jan 2018 to July 2018. This study was conducted on 100 patients which was suffering from hypertension and visit the hospital regularly. In all patients, 5 mL of fasting blood sample was taken before hemodialysis and was analyzed for serum calcium, phosphorous, albumin, PTH, and hemoglobin. Serum calcium, phosphorous, and albumin were measured. BP was obtained using an automatic BP monitor. Results: Calcium and PTH levels significantly decreased in all hypertensive patients with a cure rate of 99.1%. The mean systolic and diastolic BP decreased in the total population of hypertensive patients and hypertensive patients on antihypertensive therapy. Patients with PHPT experienced a significant decrease in both systolic BP (P < .001) and diastolic BP. Conclusion: It is concluded that the association between PTH and BP observed in this study contributes to the understanding of calcemic hormones and BP regulation