DYSLIPIDEMIA PATTERN AND IMPACT OF DURATION OF TYPE 2 DIABETES MELLITUS AND INCREASING AGE ON INSULIN RESISTANCE, INSULIN LEVELS AND DYSLIPIDEMIA

Aim: To investigate dyslipidemia pattern in patients with type 2 diabetes and to determine the correlation of increasing age and duration of the disease with dyslipidemia, insulin level and insulin resistance in diabetic patients. Methods: A cross-sectional study was held in the Medicine department of Mayo Hospital Lahore for six months duration from October 2019 to March 2020 among 112 selected patients Triglycerides, Serum total cholesterol, high density lipoproteins, low density lipoproteins, and insulin levels in both cases and control. Insulin resistance was calculated using a homeostatic model to assess insulin resistance. The correlation between the increase in age and duration of disease was determined using biochemical parameters. SPSS 17 was used for statistical analysis. Results: Of the 112 participants in the study, 72 (64%) were patients and 40 (36%) were healthy controls. Of these cases, 44 (61%) patients had hypertriglyceridemia followed by low density hypertriglyceridemia 36 (50%). Among the controls, 20 (50%) patients had low density hypertriglyceridemia followed by 17 (42.5%) hypertriglyceridemia. The duration of the disease was not correlated with dyslipidemia or insulin resistance (p> 0.05). The duration of the disease had a strong negative correlation with serum insulin levels (p = 0.03). Regression analysis showed no significant correlation with age dyslipidemia, serum insulin levels, or insulin resistance (each p> 0.05). Conclusion: Hypertriglyceridemia is the most common dyslipidemia in type diabetes, whereas hypertriglyceridemia is a risk factor in healthy people. In addition, disease duration was in reverse correlated with serum insulin levels and positively correlated with dyslipidemia. Key words: diabetes, dyslipidemia, insulin resistance